Science Ain't So Bad

Vanquished!

Diabetes: cure.

INSULIN PRODUCING BETA CELLS PROTECTED IN FOUR YEAR STUDY

Let’s see what’s new.

Ah.  Here’s a study from the Juvenile Diabetes Research Foundation about a cure for diabetes.

Now I KNOW I’m dreaming!

A new drug, otelixizumab, is in phase III trials. (Phase III trials are the randomized, controlled, multicenter trials where you figure out if the drug really works).

Forty eight  months into the study, the insulin making cells of the eighty “type 1″ patients in the study are still OK.

How’re you doin’? Hair standing up on the back of yer neck? Hands shakin’? If not you don’t get it. This is an atomic bomb! This is a breakthrough of a breakthrough! This is.. well… ScienceAintSoBadRating = 10.

MISTERScienceAintSoBad SHOULD know better than to give away 10′s like this. Something this important’s gotta be tested on more than 80 patients. Maybe the head’ll fall off of the 81st one (considered a setback). But DAMN this is neat!

Maybe there IS something to all this science stuff!

THAT'S one. (A pancreas.)

image from Creative Commons

Medicine: Type 1 Diabetes.

An artificial pancreas really is just over SOME horizon now. An announcement from Cambridge (article in the Lancet) describes the fine work of Dr Roman Hovorka at the University of Cambridge, working with a group of seventeen diabetic kids.

A cure for diabetes would be nice, of course. And there are some intriguing hints but, for now, an artificial pancreas would be stunning enough.

If it works out (and if it is widely accepted), this development has the potential to greatly reduce the complications of the disease, ease peoples’ lives, and reduce health care costs significantly (Wouldn’t THAT be nice?).

Back to which horizon this is over.

It’s hard for MISTER ScienceAintSoBad to say this but, once again, this is only a tantalizing possibility of something that is badly needed. We ARE a lot closer, thanks to the great work being done. Maybe as little are three, four or five years.

Karen Addington (Juvenile Diabetes Research Foundation) says this is a “proof of principle” and that we “need to redouble our efforts.”

I’m not sure that’s what we want to hear. But reality IS so darn real, isn’t it?

ScienceAintSoBadRating = 9

- – - – - – - – - Postscript – - – - – - – - –

Karen Addington was nice enough (and ubiquitous enough) to leave a comment which I am duplicating below since it addresses the question of when this device might really hit the road. Notice that her motivation is personal.

Her comment:

Thanks for picking up on this new research.

We know that developments like the artificial pancrease can’t come quickly enough for people living with type 1 diabetes, and their families. That’s why we’re working really hard to make sure that the artificial pancreas becomes a reality as soon as possible. In January my colleagues at JDRF International (based in the USA) announced a partnership with Animas (a Johnson & Johnson company that manufactures pumps) to develop a first generation artificial pancreas.

The goal is to develop a system that can prevent the extremes of both hypoglycaemia and hyperglycaemia automatically – but will still need some input from the wearer, such as informing the system of meal times and periods of exercise.

This partnership is planned for four years and by the end we hope to reach the point where it will ready to go forward for approval by regulatory bodies like the US Food and Drug Administration (FDA) and the European Medicines Agency (EMEA), and from there to people with type 1.

I have had type 1 diabetes for 30 years, and I’m really excited about what this research could soon mean for me, and everyone else with type 1.

Progress

Remember the difference between Type 1 Diabetes and Type 2?

Type 1′s the type where the pancreas just can’t produce insulin, period.

Without insulin you die.

So. If you’re a “Type 1″ you can plan on a regimented life of becoming an expert on your own body, carefully monitoring your glucose levels, eating with scrupulous exactitude, and self administering calibrated amounts of insulin.

With motivation, discipline, and luck, Type 1′s can have great lives. Like our new Supreme Court Justice.

But who wants to be a poster child?

Better to cure the disease.

Step by step, this thing’s going away. I really believe that.

But what if you’re waiting for a cure, watching the damage accumulate in parts of your body? Well, good news! A monkey in Virginia has seen his Type 1 diabetes reversed for a year.

Not a thousand monkey. Not a hundred monkey. Not replicated by other labs (yet). And, most certainly, not in humans. But, according to the article in the Roanoke Times, we may be a few years away from human trials.

MISTER ScienceAintSoBad is ‘sposed to love science.

He does. He does.

But it can be so SLOWWWWW.

This good work was done (mainly) at Revivicor, a small private company in Virginia. To Revivicor and a monkey that’s feeling so much better, ScienceAintSoBadRating = 9 .

(Hey. I’ll bump you up to 10 for a cure.)